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Previous studies have shown that enhanced IGF-1 signaling can result in increases in tissue weight and somatic growth (4145)

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Similar results were found in terms of function and by the 12 month follow up mark almost 80% of patients in the shockwave group were happy with their outcome compared to less than 40% in the control group

In some embodiments, the otic composition or formulation comprises less than 9% by weight of water