(PubMed) Zempleni J, Trusty TA, Mock DM
This is care built around you, not a one-size-fits-all plan
When cells are exposed to ferroptosis inducers, the SQSTM1/p62Keap1Nrf2AKR1C (metal-binding protein MT-1G) pathway is activated, and then activating transcription of quinone oxidoreductase-1, HO-1, and ferritin heavy chain-1, reducing the sensitivity of ferroptosis in the end (Sun et al., 2016b)
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Therefore, it is not appropriate most -- especially those who are pregnant, breastfeeding, have active cancer, or certain metabolic conditions