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Strong Cardiovascular & Renal Protection Evidence continues to grow: - Reduced risk of major adverse cardiovascular events (MACE) - Lower incidence of heart failure and atrial fibrillation - Protective effects in kidney disease and high-risk populations These benefits often extend beyond weight loss alone, suggesting direct biological effects

We note that we did not make a proposal to alter the substance of the overall policy excluding cell and gene therapies from the C-APC packaging

A meta-analysis incorporating data from ten tirzepatide studies and involving over 6,800 participants found that tirzepatide at 15mg/weekly resulted in a 10% discontinuation rate due to adverse effects

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