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Sex-specific differences in LPS-induced rapid myocardial dysfunction
40% lower risk of hospitalization or death High-risk patients with heart failure had an over 40 percent lower risk of hospitalization or death after initiating weight loss drugs semaglutide or tirzepatide compared to placebo by proxy, according to a study out of Harvard-affiliated Mass General Brigham
Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years