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JAMA 332 , 910 (2024)
Both semaglutide and tirzepatide are effective for weight loss, but studies show that tirzepatide (Mounjaro, Zepbound, etc) generally causes more weight loss than semaglutide (Ozempic, Wegovy, etc) due to its added GIP receptor activity in addition to GLP1
While some of this variation in results is likely attributable to the inherent variability of results between trials, some variation may be attributable to the slight differences in the patient populations between trials, where patients receiving tirzepatide in SURMOUNT-5 had a higher average waist circumference and body weight at baseline (mean [standard deviation (SD)] waist circumference 117.7 [16.1]
Wang ZK, Chen RR, Li JH, et al
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