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While we employed Steiger filtering to test the direction of causation as a sensitivity analysis, we note that its statistical power can be suboptimal when binary outcomes are involved
GLP-1 patient volume exhibited consistent and substantial growth throughout the observation period, with an initial 37.9% increase in 2019, ultimately reaching a 744.6% increase by 2023 relative to the 2018 baseline (Figure 1)
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Currently (February 2024), the EMA is considering the wider use of Wegovy to include reducing cardiovascular events this is critical for coverage in many European health systems, including the largest, Germany, which refuse to cover it for weight loss alone
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