Our 2025 analysis identified early signs of reduced consumption among GLP-1 users
3.6 Leaky gut Disruption of intestinal barrier integrity, commonly referred to as leaky gut has emerged as a key pathogenic factor in a wide range of chronic inflammatory and autoimmune diseases (Hollander and Kaunitz, 2020)
They are seeing the connections, for example, between depleted stores of this antioxidant and the likelihood of chronic disease
My skin, energy, and digestion have all improved dramatically." - Sarah K
Evidence-based alternatives For those seeking effective weight management, several proven approaches offer better value than unproven GLP-1 supplements: NHS weight management services: Free, evidence-based support through GP referral Focused on sustainable lifestyle changes Access to qualified healthcare professionals Potential pathway to prescription medications if appropriate Structured lifestyle programmes: Services like Second Nature combine behavioural psychology with nutrition support Evidence shows 19.1% weight loss at 12 months when combined with medication Address the psychological aspects of eating behaviour Build sustainable habits rather than quick fixes Whole foods approach: Instead of spending 40 monthly on supplements, invest in nutrient-dense foods Focus on protein (100-120g daily), fibre-rich vegetables, and healthy fats Create naturally satisfying meals that support metabolism Practice portion awareness and mindful eating For those requiring medical intervention: Speak with your GP about whether prescription weight loss medications are appropriate If eligible, medications like Saxenda, Wegovy or Mounjaro have robust clinical evidence These should always be combined with lifestyle changes for sustainable results Proper medical supervision ensures safety and effectiveness At Second Nature, we focus on evidence-based approaches that combine behavioural psychology with nutritional support, helping you build sustainable habits for long-term weight management without relying on unproven supplements
