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Combined use increases the risk of respiratory depression and complicates clinical management

Medications that mimic GLP-1 (like semaglutide and tirzepatide) are FDA-approved for: Type 2 diabetes management (Ozempic) Chronic weight management (Wegovy, Zepbound, and Mounjaro) These drugs help reduce appetite, slow digestion, and improve metabolic efficiencyall of which support gradual, sustainable weight loss

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Surrogate endpoint : misura di laboratorio o istologica (come il miglioramento alla biopsia epatica) utilizzata come proxy del beneficio clinico diretto (sopravvivenza, eventi epatici)