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A meta-analysis of 18 clinical trials involving more than 10,000 patients with lower limb atherosclerosis has demonstrated that lipid-lowering therapy decreases the risk of cardiovascular events by nearly 20% and reduces all-cause mortality by 14% [314]

P = 1.00), with no intergroup heterogeneity ( P = 0.13) (Additional file 1: Fig

Statistical Analysis Statistical Package for the Social Sciences (SPSS-10 Inc., Chicago, IL., USA) version 23 was used for data analysis

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