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Non-diabetic patients who received 15mg weekly for 72 weeks (about 17 months) lost an average of 22.5% of their body weight, compared to 2.4% of the placebo group

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Research published in Molecules measured the net desensitization half-life at just 2.99 minutes

Clinical experience with semaglutide and tirzepatide shows weight typically returns after discontinuation, which supports long-term use