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The Evidence: Randomized placebo-controlled studies demonstrate that Transcranial PBM significantly reduces the number of headache days per month by raising the brain's metabolic threshold and reducing cortical hyperexcitability [5]

References 1.Pope HG, Khalsa JH, Bhasin S

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Intriguingly, MOTS-c behaves like an exercise mimetic in muscle: it is an exercise-induced peptide, meaning that during physical activity the levels of MOTS-c naturally rise

As a result, reactive oxygen species (ROS) production is induced, and nitric oxide (NO) levels are decreased (14)