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Aunque en teora podra beneficiar una fase de definicin, al reducir la ingesta calrica y favorecer la prdida de grasa, los efectos secundarios pueden comprometer el rendimiento y la recuperacin

JACC 84(1):2740 Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

These are meaningful differences, though the observational design prevents definitive causal conclusions

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405 Furthermore, CRTC2 in association with CREB is also involved in the transcriptional activation of BCRP (Breast Cancer Resistant Protein)/ ABCG2, which further promotes ovarian cancer