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Independent confirmation comes from placenta-MSC transplantation in ovariectomised rats, where secreted factors activate PI3KFOXO3 to tilt oocyte growth-versus-death decisions [179], and from miR-21-overexpressing bone-marrow MSCs whose transfer of miR-21 targets PTEN/PDCD4, another brake on AKT activity, to suppress granulosa-cell apoptosis [25]