can semaglutide cause liver issues Ozempic and Wegovy ingredient may reverse signs of disease Could semaglutide one day help

As crucial regulators of local immune responses and tissue repair, macrophages in diabetic wounds show dysregulated switching from M1 to M2, resulting in a poor regenerative environment, exacerbated tissue damage, and delayed wound healing 63

This is the one that matters most here, because SCFAs are the link to GLP-1

The long half-life means that even after stopping treatment, side effects can persist for several weeks

Yet current prescribing guidelines dont recommend asking a basic question before initiating treatment: Does this patient actually have low endogenous GLP-1 levels

To put that into perspective, the average weight loss with Wegovy (semaglutide 2.4 mg) is around 17.5% over 68 weeks, and with Mounjaro (tirzepatide 15 mg), around 20% over 72 weeks