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Selective iron chelation in Friedreich ataxia: biologic and clinical implications

Introduction Androgen-deprivation therapy (ADT) is considered a cornerstone treatment option for prostate cancer, the second leading cause of cancer mortality among North American men ( Despite the significant survival advantage it confers, ADT is associated with numerous adverse effects including increased risk for cardiovascular diseases, diabetes, sexual dysfunction, cognitive, and mood dysfunction, and sleep disturbance (Siddiqui and Krauss, 2018)

Steven L

The present study aimed to test whether high doses of maternal NAC supplementation initiated at the time of IPTB diagnosis, would: (a) mitigate umbilical cord blood GSH depletion, (b) modify maternal and/or cord blood sulfur biomarkers, and (c) improve neonatal clinical outcomes associated with oxidative stress