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Muscle Integrity Models: In models of muscle-wasting conditions (e.g., dystrophic or disuse models), IGF-1 LR3 is used as a probe to evaluate how enhanced IGF signaling might affect muscle-cell survival, differentiation, and turnover dynamics

Since Zip14 KO did not completely inhibit efflux, other transporters, such as ZIP8, may also contribute, though in vivo studies are needed to confirm this