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Lactococcus ferment lysate Research from 2023 suggests that adding fermented cultures of various probiotic strains to lotion can improve skin barrier function, reduce skin redness and irritation, and boost moisturization in part by helping to prevent transepidermal water loss (TEWL).29 Matrixyl 3000 and Matrixyl synthe'6 According to a 2023 review, in a small study on 24 men, the use of Matrixyl 3000 for two months led to a reduction in wrinkle depth by 10.2% and wrinkle volume by 17.1%.30 Similarly, another small study using a product that included Matrixyl 3000 as an ingredient (among others) found that, by day 28 of use, a majority of participants (75% of 32 total subjects) expressed overall satisfaction with their skin appearance, and a significant decrease in the number, depth, and volume of wrinkles was noted by researchers.30 While its difficult to find research specifically on Matrixyl synthe'6, studies on palmitoyl tripeptide38 suggest that the ingredient stimulates the synthesis of collagen, hyaluronic acid, fibronectin (a protein important for wound healing), and laminin (proteins that play a key role in maintaining the structure of the bodys tissues)

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The more speculative work is happening outside metabolic medicine entirely

And contrary to popular belief, even the water-soluble vitamins that we pee out in excess can still have side effects, especially in the skin where they are excreted