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Shortly after these studies began, it was proclaimed in the medical community that glutathione is our body's most powerful antioxidant and the main detoxifying agent in the body, protecting cells from free radicals and oxidative stress and boosting the immune system

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Moreover, metformin treatment prevented the degradation of cartilaginous proteoglycans and collagen, reduced cartilage erosion, and caused lower OARSI scores compared with the OA model group (Fig

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