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The increase in heart rate in retatrutide trials is the side effect that regulators and clinicians are watching closely

For the latest regulatory status, refer to the MHRA medicines search page and the EMA medicines search page

However, since Retatrutide activates two additional receptors, its side effect profile has some differences worth noting in the retatrutide vs Ozempic discussion

If you can only eat two meals, aim for 40 to 50 grams each

Beyond promoting fat storage, cortisol increases cravings for high-calorie comfort foods and can trigger stress eating behaviors that override appetite suppression