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PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimers disease

Clausen A, Doctrow S, Baudry M

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Monitoring approach: Establish clear metrics (visual field, OCT, visual acuity), measure every 3-6 months, continue peptides if stable or improving, consider break if stable 12+ months on treatment, resume immediately if decline detected during break, accept ongoing use if clearly beneficial and well-tolerated

But, uh Gordon: I mean, are there dangers to overdoing it