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-MSH Analog Cyclic Heptapeptide University of Arizona Originator Literature Reported Mechanism (Literature) Non-Selective Melanocortin Receptor Agonist Pan-MCR activation (MC1R, MC3R, MC4R, MC5R) Al-Obeidi and colleagues (1989, PMID 2555512) designed Melanotan II as a non-selective melanocortin receptor agonist with 100-fold enhanced melanotropic potency versus -MSH in the lizard skin bioassay

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The supernatant was then carefully removed and SPZs were fixed with 4% paraformaldehyde (PFA) in PBS and washed