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This happens to real people, and the consequences range from intensified nausea and gastrointestinal distress to potentially dangerous side effects from an unexpected dose doubling

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Icard, P., Alifano, M., Donnadieu, E

In contrast, the powerful beta cell action of exendin-phe1 provides a potential means to avoid tolerability issues associated with high doses of other agents, and might therefore be a novel therapeutic option for T2D