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Previously, the ACHIEVE-1 study evaluated orforglipron monotherapy in people with early type 2 diabetes uncontrolled with lifestyle intervention, and demonstrated a 12 mmol/mol (1.1%) greater HbA 1c reduction and a 5.9% greater body weight reduction than placebo (Rosenstock et al, 2025)

It is important to note that Ozempic is not FDA-approved for treating high blood pressure alone

Yet, much of the mechanistic findings rely on supraphysiological Mn doses in vitro and need confirmation at physiologically relevant Mn concentrations in vivo

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Tome-Carneiro J, Larrosa M, Yanez-Gascon MJ, et al