Lancet 393 , 791846 (2019)
GLP-1 receptors (GLP-1Rs) are distributed across various organs including the pancreas, lung, stomach, intestine, kidney, heart, and diverse brain regions (Li et al., 2009
Association of GLP-1 receptor agonists with risk of suicidal ideation and behaviour: a systematic review and meta-analysis
GLP-1 plays an important role in glucose homeostasis and is secreted into the hepatic portal system in response to elevated glucose levels from food intake 10 , stimulating insulin synthesis and release from the pancreas 11
In the alpha cells of the islets, GLP-1 receptor activation suppresses glucagon secretion, a process mediated by somatostatin release from adjacent delta cells.54,57 Beyond the pancreas, GLP-1 receptors are widely expressed in extrapancreatic tissues, including the heart, vascular smooth muscle, lungs, liver, gastrointestinal tract, vagus nerve, and enteric nervous system.58 GLP-1 receptor agonists exhibit varying degrees of homology with endogenous GLP-1 but possess extended durations of action
