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Semaglutide works by mimicking the hormone GLP-1 (glucagon-like peptide-1) that targets areas of the brain involved in regulating appetite and food intake

For a closer look at supportive care alongside GLP-1 treatment, read What Is GLP-1 Support and How Can It Transform Your Weight Loss Journey

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Box 1: Recent Trump Administration Obesity Drug Initiatives In November 2025, the Trump administration announced reaching a deal with Eli Lilly and Novo Nordisk to lower the cost of their GLP-1s for Medicare, Medicaid, and those purchasing the drugs directly from the manufacturers through a new TrumpRx website

10.1016/s0968-0896(00)00294-7 76 LukaszukA.DemaegdtH.FeytensD.VanderheydenP.VauquelinG.TourwD