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This distinction matters clinically because the biological activity of GHK-Cu depends on both the peptide sequence and the copper ion

(IX) Slug can mediate activation of c-Met in a ligand-independent manner because of increased levels of fibronectin and induced integrin V function ( The HGF/c-Met axis has an important role in cellular behaviors, such as cell proliferation, migration, survival, morphogenesis and the epithelialmesenchymal transition (EMT) (Taher et al., 2002

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The implications cascade through multiple metabolic pathways