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Furthermore, our results can be generalised mostly to individuals with type 2 diabetes who are already on metformin-based background therapy, given that drug-naive individuals were recruited only in one study [22]

For composite kidney outcomes, the HR was 0.52 (95% CI 0.330.83) with SGLT2is and 0.70 (95% CI 0.590.83) without SGLT2is ( P -value for interaction 0.38) (Table 3)

"The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats." Journal of Physiology Paris

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