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Serum limitation-induced organ culture model of keloids and apoptotic induction of FOXO4-DRI in situ The keloid tissues were cut into 4-mm diameter cylinders using a corneal trephine for organ culture and cultured in a DMEM containing 2% FBS for 10 days to construct the serum limitation-induced senescent organ culture model of keloid tissues

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The broader picture is that the next generation of obesity treatments involves multi-target approaches, whether through single molecules activating multiple receptors (tirzepatide, retatrutide, survodutide, mazdutide) or through combination therapies pairing separate compounds (CagriSema)

GGT1 knockdown cell lines had minimal GGT1 mRNA (Extended Data Fig

The mRNA levels of pathway inhibitors, such as GSK-3 and DKK1, decreased