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doi: 10.1016/j.trsl.2020.03.012, Summary Keywords aging, exercise, L-citrulline, leucine, musclevasculature, cognitive frailty, successful aging, neurovascular coupling Citation Lin X, Zhang Y, Pu J and Peng Y (2026) Targeting musclevasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention

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gain-of-function mutations in voltage-gated sodium channel genes increase neuronal excitability and are associated with PDPN