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John Richie and Calvin Lang proposed the Glutathione Deficiency Hypothesis and propose that low levels of glutathione are a key factor in the aging process.[4] In every species of animals tested, raising glutathione levels has resulted in improved health and increased longevity.ie

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They can also be toxic in the liver, bone marrow, and spleen and cause immunogenicity by attaching to the reticuloendothelial system [13]

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