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Similarly, in another randomized controlled trial that included children and adolescents with obesity and insulin resistance based on HOMA-IR, there was no significant difference in HbA1c or HOMA-IR when comparing Metformin to placebo over 18 months of therapy (133)

An endocrinologist is a healthcare professional who specializes in diagnosing and treating hormone-related conditions affecting the endocrine system

doi: 10.1038/s41580-023-00648-1 47 WangYQChangSYWuQGouYJJiaLCuiYMet al

Pivotal trials: what the NEJM data show Semaglutide STEP-1 (2021) and SELECT (2023) STEP-1 (Wilding et al., NEJM 2021) randomized 1,961 adults over 68 weeks on semaglutide 2.4 mg/week

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