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Quantitation of in vivo brain glutathione conformers in cingulate cortex among age-matched control, MCI, and AD patients using MEGA-PRESS

A recent study in female Chinese women with gallstones has shown reduced NCP1-L1 mRNA and protein in the liver and supersaturation of cholesterol in the bile [109]

Importantly, a series of standardized toxicological assessments confirmed the safety of UA, showing favorable profiles in both human and animal models, with minimal side effects (7, 9)

Future work will use longitudinal profiling and single-cell sequencing to assess cell-type-specific GSH roles 5 Conclusion In conclusion, by leveraging multi-omics integration, the present study identified GSH metabolism as a pivotal node in SAE, while providing a comprehensive molecular framework for SAE pathogenesis, and linking microglia-driven neuroinflammation to hippocampal oxidative damage