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In Sas Pcob, the close interaction and relative position of the B 12 - and BV-binding domains brings the two chromophores in close proximity, with the edge of the BV C and D rings within van der Waals distance of the conserved Trp61 and the corrin ring B, respectively

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Thus, while identifying ferroptosis as an aspect of the macrophage in CD, much remains to be done to understand the physiological and pathophysiological implications of death pathways in myeloid cells