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However, it is unsafe for pregnant or breastfeeding women, as it can cause serious congenital disabilities and developmental issues in babies

JHU-083 markedly suppresses the recruitment of MDSCs by decreasing tumor-derived CSF3 levels via degradation of C/EBP, which in turn increases the numbers of proinflammatory TAMs and enhances antigen presentation to CD8(+) T cells, resulting in stronger T-cell responses 150

In animal studies, the enhancement of adipocyte mitochondrial biogenesis results in increased adiponectin release from adipose tissue

Kahweol ameliorates cisplatin-induced acute kidney injury through pleiotropic effects in mice

Therefore, to eliminate the potential baseline effect of different studies, the rates of body weight change from the initial values were selected as the therapeutic index, which was a better indicator used to assess changes in body weight