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Notably, although there was not a statistically significant increase in biliary disease among GLP-1 receptor agonist users in this study, the FDA 2 added warnings and precautions about acute cholecystitis and biliary disease to the label in late 2022 based on data from placebo-controlled RCTs as well as other observational data 3

Phase 3 adds a 6 mg step, creating a smoother escalation that reduces the size of each dose increase

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Managing GLP-1 Side Effects Managing the side effects of GLP-1 medications is essential for maintaining long-term success in treatment