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This contraindication mirrors the warnings on GLP-1 receptor agonists and reflects precautionary data from animal studies rather than confirmed human risk

N Engl J Med 1987;317:812-8

Oxygen flux rates were normalized to mg of protein added determined with a BCA protein analysis test (Pierce)

Furthermore, as persulfides have a low pKa (~4.3) they are largely in the thiolate form in vivo, and due to the -effect of the non-terminal S atom are better nucleophiles than thiols 29

[4] The second activation step takes place predominantly in the kidneys where 1-hydroxylase converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (calcitriol), an active secosteroid hormone that binds nuclear receptors in enterocytes, osteoblasts, renal tubules, parathyroid cells, and numerous immune and endocrine cells to modulate hundreds of genes involved in calcium-phosphate homeostasis, skeletal remodelling, and immunoregulation