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By using AI to analyze more than 400,000 Reddit posts, researchers at Penns School of Engineering and Applied Science have identified patient-reported symptoms associated with GLP-1s, the popular weight-loss and diabetes drugs semaglutide and tirzepatide, that may not be fully captured in clinical trials or regulatory documents

In studies of tirzepatide, some people lost as much as 25% of their starting weight over 88 weeks

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If you take insulin or sulfonylureas with GLP-1 therapy, check your blood glucose when experiencing cognitive symptoms, as hypoglycemia can mimic brain fog

The former is currently awaiting FDA approval for a handful of oral, daily GLP-1 agonists, while the latter is developing combination therapies that use their muscle-preserving antibodies, trevogrumab and garetosmab, alongside GLP-1 drugs like Wegovy and Ozempic, to improve fat loss while preserving muscle mass