The cause of FD remains to be established, but recent data suggest that infections, brain-gut disturbances, duodenal perturbations and food may play a crucial role in pathophysiology of FD (6)
Unlike peptide-based GHS compounds, MK-677 does not require injection and has a prolonged half-life that results in sustained rather than pulsatile GH elevation
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This stability property was observed early and supported the use of oral and intragastric dosing routes in a number of animal experiments a meaningful characteristic in preclinical research design