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fMRI was also used to evaluate the central effects of GLP-1RAs

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4.4.2 Mechanistic insights in non-cirrhotic MASLD/MASH In non-cirrhotic MASLD/MASH, chronically elevated circulating BCAAs promote hepatic lipogenesis through several mechanisms

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In clinical trials, tirzepatide produced somewhat greater average weight loss, likely because it works on two hormone pathways (GLP-1 and GIP) instead of one