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2012;7(8):e43484

CpG island methylation can silence tumor suppressor genes and increase the possibility of mutations, which often occur in these regions

Seminal randomized controlled trials by Creagan and Moertel administering oral VC (10 g/day) failed to replicate Camerons reported survival benefits in terminal cancer patients, casting doubt on VCs clinical utility ( 2 O 2 generation ( KRAS )-mutant tumor regression, lower doses (510 mM) paradoxically enhance glutathione synthesis in 32% of glioblastoma cases ( TET1 ) -mediated MMP-9 downregulation, yet population studies associate supplemental VC with 1.3-fold increased recurrence risk in ER + breast cancer ( In this review, we synthesize mechanistic insights from redox biology and immunometabolism with clinical trial data to propose a framework for optimizing VC-based combination therapies (Graphical abstract)

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