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A contaminated vial must be discarded

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This localized tolerogenic niche reduced mean paralysis levels and sharply diminished CNS infiltration of Th1/Th17 cells, establishing antigen-specific tolerance without systemic immunosuppression

Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))

& Caiafa, P