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NIH Consensus Statement 1992;10:133

Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine

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At present, it is clear that the inactivation of the so-called PTPRV gene (encodes a tyrosine phosphatase present in stem cells, Sertoli cells and osteoblasts) has a positive effect on B-cell proliferation and insulin secretion