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Additionally, the commenter stated that in the CY 2026 OPPS/ASC proposed rule, CMS appropriately acknowledged that the LithoVue TM Elite Ureteroscope may fall within the scope of the existing device category C1747, which includes all single-use ureteroscopes and their associated procedures

These studies suggest that Ex-4 regulates the level of HIF-1 in the nerve cell which may play a significant part in the neuroprotection of Ex-4 against hypoxic-ischemic

Endothelial dysfunction increases BBB permeability, allowing harmful substances and inflammatory cells from the bloodstream to infiltrate the brain parenchyma, inducing cerebral edema and exacerbating neuronal damage (40)

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