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Furthermore, DPP4 inhibitors modify the relative levels of intact vs cleaved substrates (Figure 2), which may exhibit varying affinities for structurally related receptors (Figure 3), further complicating assignment of mechanistic roles for key peptide substrates in transducing actions arising from DPP4 inhibition

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For the determination of S -allyl-L-cysteine, a mobile phase composed of 67 mM sodium citrate, 8% (v/v) ethanol, and 0.01% (v/v) octanoic acid (pH 3.26) was used for an isocratic elution