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GLP-1 agonists trigger the pancreas to release insulin, lowering the amount of glucose (sugar) in the blood

In some cases, this can lead to jaundice, which is a yellowing of the skin or the whites of the eyes

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Methods In a single-dose, first-in-human trial, 135 healthy males received oral semaglutide (220 mg semaglutide co-formulated with 150600 mg SNAC) or placebo with SNAC

For people with type 2 diabetes, insulin and sulfonylureas carry an additional risk of hypoglycaemia if used alongside retatrutide, and dose adjustments should only be made under close clinical supervision