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Mice were group-housed by gender at 20-24C, 45-65% humidity and exposed to a 12-hour light/12-hour dark period

Discrepancies were resolved by consensus, with arbitration by a third author (V.M.) when necessary

If it is stored at room temperature, get rid of any unused medication after 28 days or after it expires, whichever is first

Typical Weekly Pattern During This Phase Weight loss: 0-0.5 pounds weekly average, with frequent plateau weeks Appetite: Remains suppressed compared to baseline but increased compared to weeks 8-28 Energy: Stable at levels established in weeks 25-36 Side effects: Essentially none

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