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A new buffer is established at the beginning of each Target Outcome Period and is dependent on prevailing market conditions

The excluded products typically fall into one or more of the following categories: Brand-name products with generic equivalents or therapeutic alternatives Biosimilars and reference biologics with biosimilar alternatives Non-preferred drugs with low utilization Heavily promoted drugs in therapeutic classes with multiple generic alternatives Medicines treating chronic conditions IN THE YEAR 2025 Here are my three takeaways from the 2025 exclusions

What's particularly fascinating is the timing patients experience noticeable improvements in their most troublesome symptoms within 2-4 weeks of starting low-dose GLP-1 therapy, much faster than traditional MCAS treatments that can take months to show benefit

Our findings support decision-making in clinical practice in patients with an indication to switch between GLP-1 RAs

Supplements may modestly support that production