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Clinically, these insights suggest that routine metabolic profilingespecially of carnitine-acylcarnitine pathwayscould serve as a valuable adjunct in assessing treatment response and guiding individualized therapy
Clinical trials have shown that metformin alone leads to an average weight loss of about 5 percent of body weight for roughly a third of people who take the drug, including loss of about 12 to 15 pounds in people without diabetes
Hope et al
The New England Journal of Medicine, 393 (11), 10651076.doi: 10.1056/NEJMoa2505669
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