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These factors have a greater impact on some stages of life, such as the first thousand days, since they change the expression of genes that regulate hunger/satiety regulatory systems, energy expenditure, and adipogenesis [8]

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Both alcohol and isoniazid induce CYP2E1 and affect APAP-induced ALI by increasing NAPQI, the hepatotoxic metabolite of APAP, indicating that CYP2E1 may be the major P450 contributing to conversion of APAP to NAPQI (Zand et al., 1993

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