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By 2024, research expanded the cardio-renal framework to include hepatic dysfunction, recognizing its role in metabolic disturbances disturbances ( In February 2025, Theodorakis and Nikolaou proposed an expanded framework transitioning from CKM to CRHM syndrome ( 3 Pathophysiology of cardio-renal-hepatic-metabolic syndrome The pathophysiology of CRHM syndrome is driven by a multifaceted interaction of unified mechanisms, creating a self-perpetuating cycle of multi-organ dysfunction

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doi: 10.1080/1061186X.2024.2389892 269 AryaPRaghavN